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Clinical trials for Internal Fixation

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43881   clinical trials with a EudraCT protocol, of which   7295   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    19 result(s) found for: Internal Fixation. Displaying page 1 of 1.
    EudraCT Number: 2006-001832-34 Sponsor Protocol Number: 3100N7-211-WW Start Date*: 2007-01-11
    Sponsor Name:Wyeth Pharmaceuticals Inc.
    Full Title: A Phase 2, Multicenter, Single-Blind, Randomized, Stratified, Standard-of-Care Controlled, Feasibility and Safety Study of rhBMP-2/CPM as an Adjuvant Therapy for Fractures of the Proximal Femur
    Medical condition: Closed fracture of the proximal femur
    Disease: Version SOC Term Classification Code Term Level
    8.1 10020100 Hip fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) FI (Completed) HU (Completed) FR (Completed) SE (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2009-015939-33 Sponsor Protocol Number: 20080394 Start Date*: 2010-03-23
    Sponsor Name:Amgen Inc
    Full Title: A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Determine the Efficacy, Safety, and Tolerability of AMG 785 in Adults with Fresh Unilateral Intertrochanteric Fracture of the P...
    Medical condition: Acceleration of fracture healing
    Disease:
    Population Age: Gender: Male, Female
    Trial protocol: FR (Completed) GB (Completed) DE (Completed) SE (Completed) PL (Completed) DK (Completed) NL (Completed) LV (Completed) GR (Completed) IT (Completed) HU (Completed) BE (Completed) FI (Completed) LT (Completed) EE (Completed) BG (Completed) SI (Completed)
    Trial results: View results
    EudraCT Number: 2005-003635-46 Sponsor Protocol Number: 05/MRE10/72 Start Date*: 2006-05-16
    Sponsor Name:NHS Lothian University, Research & Development
    Full Title: Do Anti-Oxidants Modulate the Outcome of Fractures? The Effect of Vitamin C on Functional Outcome Following Fracture of Distal Radius: A Prospective randomised controlled trial.
    Medical condition: Adult patients with fractures of the distal radius.
    Disease:
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2011-001116-65 Sponsor Protocol Number: B3D-MC-GHDQ Start Date*: 2012-02-10
    Sponsor Name:Eli Lilly and Company
    Full Title: Second study on the Effect of Teriparatide on Femoral Neck Fracture Healing
    Medical condition: Low trauma femoral neck fracture
    Disease: Version SOC Term Classification Code Term Level
    14.1 100000004863 10068399 Trochanteric femoral fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: HU (Completed) BE (Completed) GR (Completed) PL (Completed) NL (Completed) DE (Completed)
    Trial results: View results
    EudraCT Number: 2010-021395-28 Sponsor Protocol Number: B3D-MC-GHDN Start Date*: 2012-04-03
    Sponsor Name:Eli Lilly and Company
    Full Title: Effect of Teriparatide on Femoral Neck Fracture Healing
    Medical condition: Low trauma femoral neck fracture
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10016450 Femoral neck fracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Completed) ES (Completed) LV (Completed) FI (Completed) NO (Completed) LT (Completed) EE (Completed) DK (Completed)
    Trial results: View results
    EudraCT Number: 2009-010708-28 Sponsor Protocol Number: none02 Start Date*: 2009-07-03
    Sponsor Name:Department of Anaesthesia
    Full Title: Does the stellate ganglion block improve postoperative analgesia following upper limb trauma?
    Medical condition: We propose that the sympathetic nervous system contributes to acute pain and that a sympathetic nerve block, the stellate ganglion block, will improve postoperative pain in patients presenting for ...
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10054711 Postoperative pain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2006-003688-30 Sponsor Protocol Number: CS I-040101/02 Start Date*: 2007-02-27
    Sponsor Name:Kuros Biosurgery AG
    Full Title: A phase 2 randomized, controlled, open-label (dose-blinded), multi-center, dose-finding study of the safety and efficacy of I-0401 in the treatment of patients with fractures of the tibial plateau ...
    Medical condition: Fractures of the tibial plateau requiring grafting
    Disease: Version SOC Term Classification Code Term Level
    13.1 10028395 - Musculoskeletal and connective tissue disorders 10024956 Lower limb fractures HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed) DE (Completed) ES (Completed) IT (Completed) FR (Completed) HU (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-005601-22 Sponsor Protocol Number: poc1doxy Start Date*: 2008-03-27
    Sponsor Name:
    Full Title: Proof–of–concept study 1 (POC1): Evaluation of effect of doxycycline versus placebo on retinal function and posterior segment neovascularization in patients with severe non-proliferative or early ...
    Medical condition: Diabetic retinopathy
    Disease: Version SOC Term Classification Code Term Level
    9.1 10012689 Diabetic retinopathy LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: (No results available)
    EudraCT Number: 2009-012672-27 Sponsor Protocol Number: CIP0702PLF/EU Start Date*: 2009-08-17
    Sponsor Name:ApaTech Limited
    Full Title: "A prospective, randomised study comparing the use of Actifuse™ ABX synthetic bone substitute with INFUSE® in patients requiring posterolateral instrumented lumbar fusion with interbody fusion" als...
    Medical condition: Prospective trial participants will have been diagnosed with degenerative disc disease with a treatment option of decompression and Interbody Fusion with Posterolateral Intertransverse Process Fusi...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024992 Lumbar disc disease LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: NL (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2015-000229-35 Sponsor Protocol Number: 2015/01 Start Date*: 2016-11-03
    Sponsor Name:Beaumont Hospital
    Full Title: A prospective randomised control trial comparing local anaesthetic subcutaneous wound injection versus local anaesthetic wound percolation in distal forearm fractures
    Medical condition: Fracture of distal radius or ulna
    Disease:
    Population Age: Adults Gender: Male, Female
    Trial protocol: IE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2004-002344-99 Sponsor Protocol Number: SKY0402-C-203 Start Date*: 2005-03-03
    Sponsor Name:SkyePharma, Inc.
    Full Title: A Phase 2, Multicenter, Randomized, Double-Blind, Dose-Escalating/De-Escalating Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Sustained-Release Encapsulated Bupivacaine (SKY0402) ...
    Medical condition: Pain following bunionectomy
    Disease: Version SOC Term Classification Code Term Level
    6.0 10006586 LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: (No results available)
    EudraCT Number: 2015-001108-76 Sponsor Protocol Number: 2015-735 Start Date*: 2015-04-30
    Sponsor Name:Herlev Hospital, Department of Anaesthesiology I65N9
    Full Title: "AnAnkle Trial": Peripheral nerve block vs. spinal anaesthesia for ankle fracture surgery – implications on pain profile and quality of recovery
    Medical condition: Ankle fracture (anaesthesia for surgery)
    Disease: Version SOC Term Classification Code Term Level
    18.0 100000004863 10054865 Malleolar fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Completed)
    Trial results: View results
    EudraCT Number: 2006-001831-23 Sponsor Protocol Number: 3100N7-210 WW Start Date*: 2007-01-23
    Sponsor Name:Wyeth Pharmaceuticals Inc.
    Full Title: A Phase 2/3, Multicenter, Double-Blind, Randomized, Controlled Study of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP 2)/Calcium Phosphate Matrix (CPM) in Closed Diaphyseal Tibial Fractures
    Medical condition: Closed diaphyseal tibial fracture
    Disease: Version SOC Term Classification Code Term Level
    8.1 10043827 Tibia fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) SE (Completed) DE (Prematurely Ended) FI (Completed) GB (Completed) LV (Completed) SI (Prematurely Ended) BG (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2006-005093-40 Sponsor Protocol Number: CS I-040202/01 Start Date*: 2007-10-22
    Sponsor Name:Kuros Biosurgery AG
    Full Title: A phase II randomized, controlled, open-labeled (dose-blinded) dose finding study of the safety and efficacy of I-040202 in the treatment of patients with acute open tibial shaft fractures
    Medical condition: Acute open tibial shaft fractures
    Disease: Version SOC Term Classification Code Term Level
    9.1 10024956 Lower limb fractures HLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed) FR (Completed) HU (Completed) SI (Completed) FI (Completed) CZ (Completed) SK (Completed) IT (Completed) BG (Completed)
    Trial results: (No results available)
    EudraCT Number: 2011-000988-28 Sponsor Protocol Number: 19403 Start Date*: 2011-08-16
    Sponsor Name:University of Edinburgh [...]
    1. University of Edinburgh
    2. NHS Lothian
    Full Title: Fractures and Bisphosphonates: A double-blind, randomised controlled trial on the effect of alendronic acid on healing and clinical outcomes of wrist fractures
    Medical condition: Fracture healing
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10017076 Fracture PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2018-001630-18 Sponsor Protocol Number: CWL15001 Start Date*: 2023-09-20
    Sponsor Name:5med GmbH
    Full Title: A randomized, parallel group, multi-center study of a fentanyl nasal spray compared with placebo nasal spray for postoperative pain management and prolonged open treatment over up to 120 hours post...
    Medical condition: Management of pain following orthopedic surgery
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10036236 Postoperative pain relief LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Ongoing) BG (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2007-001477-29 Sponsor Protocol Number: CR9-108914 Start Date*: 2007-09-10
    Sponsor Name:GlaxoSmithKline R & D Limited
    Full Title: A proof-of-concept study of SB-751689 in men and post-menopausal women with a fractured distal radius.
    Medical condition: Distal radius fracture
    Disease: Version SOC Term Classification Code Term Level
    9.1 10017076 Fracture LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: SE (Prematurely Ended) NL (Prematurely Ended) ES (Completed) CZ (Prematurely Ended) GB (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2010-024115-14 Sponsor Protocol Number: 05-AnIt-09/UKM10_0027 Start Date*: 2011-04-29
    Sponsor Name:University Hospital Muenster
    Full Title: Preoperative Intravenous Ferric Carboxymaltose (Ferinject) in Patients with Orthopaedic Surgery and High Risk of Blood Loss
    Medical condition: Patients with iron deficiency anemia scheduled to undergo orthopedic surgery with high risk of bleeding
    Disease: Version SOC Term Classification Code Term Level
    14.1 10042613 - Surgical and medical procedures 10058829 Elective surgery PT
    14.1 10042613 - Surgical and medical procedures 10044088 Total hip replacement LLT
    14.1 10022117 - Injury, poisoning and procedural complications 10005127 Bleeding postoperative LLT
    14.1 10005329 - Blood and lymphatic system disorders 10066573 Chronic iron deficiency anemia LLT
    14.1 10042613 - Surgical and medical procedures 10057129 Revision of total knee arthroplasty LLT
    14.1 10022117 - Injury, poisoning and procedural complications 10051536 Intraoperative bleeding LLT
    14.1 10005329 - Blood and lymphatic system disorders 10022975 Iron deficiency anemia secondary to blood loss (chronic) LLT
    14.1 10042613 - Surgical and medical procedures 10069749 Internal fixation of spine PT
    14.1 10022117 - Injury, poisoning and procedural complications 10051386 Wound bleeding LLT
    14.1 10042613 - Surgical and medical procedures 10020096 Hip arthroplasty PT
    14.1 10005329 - Blood and lymphatic system disorders 10022976 Iron deficiency anemia secondary to inadequate dietary iron intake LLT
    14.1 10042613 - Surgical and medical procedures 10051060 Hip surgery PT
    14.1 10042613 - Surgical and medical procedures 10039727 Scoliosis surgery PT
    14.1 10042613 - Surgical and medical procedures 10049130 Back surgery LLT
    14.1 10042613 - Surgical and medical procedures 10023469 Knee arthroplasty PT
    14.1 10005329 - Blood and lymphatic system disorders 10022977 Iron deficiency anemia, unspecified LLT
    14.1 10042613 - Surgical and medical procedures 10020102 Hip replacement LLT
    14.1 10042613 - Surgical and medical procedures 10057128 Revision of hip arthroplasty LLT
    14.1 10042613 - Surgical and medical procedures 10044094 Total knee replacement LLT
    14.1 10042613 - Surgical and medical procedures 10049662 Knee surgery NOS LLT
    14.1 10005329 - Blood and lymphatic system disorders 10022974 Iron deficiency anemia LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2009-018173-31 Sponsor Protocol Number: POISE-2 Start Date*: 2011-02-25
    Sponsor Name:Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
    Full Title: Ensayo clínico factorial de clonidina y aspirina en pacientes que van a ser sometidos a cirugía no cardiaca y que estén en riesgo moderado o alto de sufrir eventos cardíacos perioperatorios (Estudi...
    Medical condition: Prevención de episodios cardiovasculares en pacientes de moderado a alto riesgo cardiovascular que son sometidos a una cirugía no cardiaca.
    Disease: Version SOC Term Classification Code Term Level
    9 10007649 Cardiovascular disorder LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) IT (Completed) AT (Completed) BE (Completed) DK (Completed) GB (Completed) DE (Ongoing)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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